Determination of serum 25-hydroxyvitamin D status among population in southern China by a high accuracy LC-MS/MS method traced to reference measurement procedure

Autor: Zhiliang Cai, Qiaoxuan Zhang, Ziqiang Xia, Songbai Zheng, Lilan Zeng, Liqiao Han, Jun Yan, Peifeng Ke, Junhua Zhuang, Xinzhong Wu, Xianzhang Huang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-13 (2020)
Druh dokumentu: article
ISSN: 1743-7075
DOI: 10.1186/s12986-020-0427-7
Popis: Abstract Objective We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace to reference measurement procedure. Materials and methods From January 2018 to June 2019, a total of 4775 southern Chinese individuals were evaluated in our study. The serum levels of parathyroid hormone (PTH) were detected simultaneously in 162 cases. 25(OH)D was determined by LC-MS/MS, and PTH was detected using routine automated analysers. The distribution of the concentration, prevalence and seasonal variability of 25(OH)D in males and females of different age groups were studied. Results The mean 25(OH)D concentration in our study was 32.57 ng/mL (4.20–101.40 ng/mL). The global 25(OH)D concentration in males was higher than that in females of different age group. The prevalence of vitamin D deficiency (
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