Brain Tumor Heterogeneity
| Autor: | Telmo Augusto Barba Belsuzarri, Maick Willen Fernandes Neves, Otávio Augusto da Costa, Diego Alves Soares, Fernando Antônio de Melo Filho, Mariana Mazzuia Guimarães, Tiago Fernandes Gonçales, Wolnei Marques Zeviani, João Flávio Mattos Araújo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Brazilian Neurosurgery, Vol 40, Iss 03, Pp e253-e256 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0103-5355 2359-5922 |
| DOI: | 10.1055/s-0038-1625962 |
| Popis: | Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic inflammation, microenvironment, epigenetics and glioma steam cells. Brain tumors remain a challenge with regards to medication and disease, due to the lack of treatment options and unsatisfactory results. These results might be the result of the brain tumor heterogeneity and its multiple resistance mechanisms to chemo and radiotherapy. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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