An Evaluation of the Role of OTC [(−)-2-Oxo-4-thiazolidinecarboxylic acid] in Acquisition and Expression of Morphine Dependence in Male NMRI Mice
| Autor: | H Sohrabian, H Sahraei, B Hatef, GH Meftahi |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 19, Iss 5, Pp 61-67 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 25020382 |
| Popis: | BACKGROUND AND OBJECTIVE: In morphine dependence, the concentration of natural antioxidants decreases and glutathione is one of the most important ones. Therefore, antioxidants may reduce morphine withdrawal symptoms. Therefore, the present study was conducted to analyze the effect of various concentrations of OTC [(−)-2-Oxo-4-thiazolidinecarboxylic acid] (glutathione transferase activator) on acquisition and expression of morphine dependence. METHODS: In this experimental study, small male NMRI mice (20 – 30 g) were divided into 9 groups (n = 8). The mice became morphine-dependent using Marshall Method. The animals were administered with various concentrations of OTC (5, 10, 20 mg/kg) on days of inducing dependence (reception) or days of test (expression). Two main symptoms of withdrawal syndrome (the number of jumps and the weight of stools) were evaluated by administration of naloxone. FINDINGS: Administration of naloxone in the mice that received morphine on previous days increased the weight of stools (0.62±0.2 and 0.3±0.05 in morphine and saline group, respectively) and the number of jumps (46±15 and 1±0.2 in morphine and saline group, respectively; p |
| Databáze: | Directory of Open Access Journals |
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