Molecular Investigation of Tularemia Outbreaks, Spain, 1997–2008

Autor: Jaime Ariza-Miguel, Anders Johansson, María Isabel Fernández-Natal, Carmen Martínez-Nistal, Antonio Orduña, Elías F. Rodríguez-Ferri, Marta Hernández, David Rodríguez-Lázaro
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 20, Iss 5, Pp 754-761 (2014)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid2005.130654
Popis: Tularemia outbreaks occurred in northwestern Spain in 1997–1998 and 2007–2008 and affected >1,000 persons. We assessed isolates involved in these outbreaks by using pulsed-field gel electrophoresis with 2 restriction enzymes and multilocus variable number tandem repeat analysis of 16 genomic loci of Francisella tularensis, the cause of this disease. Isolates were divided into 3 pulsotypes by pulsed-field gel electrophoresis and 8 allelic profiles by multilocus variable number tandem repeat analysis. Isolates obtained from the second tularemia outbreak had the same genotypes as isolates obtained from the first outbreak. Both outbreaks were caused by genotypes of genetic subclade B.Br:FTNF002–00, which is widely distributed in countries in central and western Europe. Thus, reemergence of tularemia in Spain was not caused by the reintroduction of exotic strains, but probably by persistence of local reservoirs of infection.
Databáze: Directory of Open Access Journals
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