| Autor: |
Zichen Ji, Julio Hernández-Vázquez, Marta Esteban-Yagüe, Paula García-Valentín, José María Bellón-Cano, Irene Milagros Domínguez-Zabaleta, Ismael Ali-García, Carmen Matesanz-Ruiz, María Jesús Buendía-García, Javier de Miguel-Díez |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Open Respiratory Archives, Vol 4, Iss 4, Pp 100212- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2659-6636 |
| DOI: |
10.1016/j.opresp.2022.100212 |
| Popis: |
Introduction: Chronic obstructive pulmonary disease (COPD) is a respiratory pathology with high prevalence, morbidity and mortality. The Spanish COPD guideline (GesEPOC) recommends individualizing treatment according to phenotypes. The phenotype classification was updated in 2021. This study aimed to determine the survival of patients by this new classification and compare the predictive capacity of mortality compared to the previous version. Methods: This observational study of COPD patients involved prospective follow-up for 6 years. Demographic and clinical data were collected at the beginning and evolutionary data at the end of the study. Patients were classified according to GesEPOC 2017 and GesEPOC 2021. Univariate survival analysis and multivariate analysis identified mortality risk factors. Results: Of the 273 patients, 243 (89.0%) were male. Ninety-three patients (34.1%) died during follow-up. Regarding phenotypes, 190 patients (69.6%) were non-exacerbators, 69 (25.3%) belonged to the non-eosinophilic exacerbator phenotype and 14 (5.1%) were of the eosinophilic exacerbator phenotype. Compared with non-exacerbator patients, those with the non-eosinophilic exacerbator phenotype had lower survival (p = 0.009). Risk factors independently associated with mortality were older age (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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