Pulmonary Vascular Volume by Quantitative CT in Dyspneic Smokers with Minor Emphysema

Autor: Amany F. Elbehairy, Sandra G. Vincent, Devin B. Phillips, Matthew D. James, Jenna Veugen, Grace Parraga, Denis E. O’Donnell, J. Alberto Neder
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: COPD, Vol 20, Iss 1, Pp 135-143 (2023)
Druh dokumentu: article
ISSN: 1541-2555
1541-2563
15412555
DOI: 10.1080/15412555.2023.2169121
Popis: Reduced lung diffusing capacity for carbon monoxide (DLCO) at rest and increased ventilation (⩒E)-carbon dioxide output (⩒CO2) during exercise are frequent findings in dyspneic smokers with largely preserved FEV1. It remains unclear whether low DLCO and high ⩒E-⩒CO2 are mere reflections of alveolar destruction (i.e. emphysema) or impaired pulmonary perfusion in non-emphysematous tissue contributes to these functional abnormalities. Sixty-four smokers (41 males, FEV1= 84 ± 13%predicted) underwent pulmonary function tests, an incremental exercise test, and quantitative chest computed tomography. Total pulmonary vascular volume (TPVV) was calculated for the entire segmented vascular tree (VIDA Vision™). Using the median % low attenuation area (-950 HU), participants were dichotomized into “Trace” or “Mild” emphysema (E), each group classified into preserved versus reduced DLCO. Within each emphysema subgroup, participants with abnormally low DLCO showed lower TPVV, higher ⩒E-⩒CO2, and exertional dyspnea than those with preserved DLCO (p
Databáze: Directory of Open Access Journals
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