| Autor: |
Zeynep Karakas, Ayse Erol, Demet Kivanc, Mediha Suleymanoglu, Hayriye Senturk Ciftci, Cigdem Cinar, Serap Karaman, Mustafa Bilici, Aysegul Unuvar, Deniz Tugcu, Gulsah Tanyildiz, Fatma Savran Oguz, Yasin Yilmaz |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Hematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S26-S27 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2531-1379 |
| DOI: |
10.1016/j.htct.2021.10.996 |
| Popis: |
Objective: HLA class I and II alleles are shown to be associated with certain diseases. A restricted numbers of alleles were found to be related to alloimmunisation in thalassemia population. The role of human leucocyte antigens in thalassemia is trend topic. In this study, the aim was to evaluate the differences in HLA frequencies of beta thalassemia patients comparing with healthy controls. Methodology: The data were collected of 100 patients who were diagnosed with beta thalassemia and 100 healthy controls were included in the study. The low resolution HLA-A, -B, -DRB1, tissue group data were performed Istanbul University, Faculty of Medicine, Medical Biology Department HLA typing laboratory. All data were analyzed retrospectively and their HLA allele frequencies were analyzed by SPSS (v22) program. Results: We found an increased frequency of HLA-B*14 (8% versus 2%) and HLA-B*52 (17% versus 2%) compared to the control group (p=0.05, OR=4.26; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
