Alcohol‐induced impaired insulin secretion in a Japanese population: 5‐year follow up in the Gifu Diabetes Study

Autor: Natsumi Ueda, Mayumi Yamamoto, Mitsuhiro Nakamura, Yumi Motooka, Yoko Nakayama, Yukiko Nonoyama, Shino Oba, Yukio Horikawa, Chisato Nagata, Daisuke Yabe, Gifu Diabetes Study Group
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 11, Iss 5, Pp 1207-1214 (2020)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13260
Popis: Abstract Aims/Introduction Although moderate alcohol consumption lowers the risk of type 2 diabetes in European populations, the same cannot be assumed for Japanese patients with diabetes related to low insulin secretion rather than resistance. We aimed to evaluate the effects of daily alcohol consumption on glucose tolerance and diabetes development risk in Japanese populations. Materials and methods This retrospective study randomly enrolled 452 men and 659 women aged 40–78 years in 2005 (Gifu, Japan). The participants completed a 75‐g oral glucose tolerance test and medical questionnaire. The homeostasis model assessment of insulin resistance, homeostasis model assessment of β‐cell function and insulinogenic index were used to estimate insulin sensitivity and secretion. The relationships between alcohol consumption and these parameters were analyzed using logistic regression after adjusting for potential confounders. The 5‐year changes in hemoglobin A1c levels were also evaluated. Results The adjusted odds ratios for elevated homeostasis model assessment of β‐cell function values (
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