Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders
| Autor: | Selin Aktan Guloksuz, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F. Leckman |
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| Jazyk: | English<br />Portuguese |
| Předmět: | |
| Zdroj: | Brazilian Journal of Psychiatry, Iss 0 |
| Druh dokumentu: | article |
| ISSN: | 1809-452X 1516-4446 |
| DOI: | 10.1590/1516-4446-2015-1843 |
| Popis: | Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS). Results: Concentrations of both S100B and TNF-α were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-α concentrations. Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-α provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder. |
| Databáze: | Directory of Open Access Journals |
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