Relation of Paraoxonase1, Arylesterase and Lipid Profile in Ischemic Stroke Patients
| Autor: | Seema Sanjay Chawhan, Mukund R Mogarekar, Reena V Wagh, Rajkumar R Das, Sanjay S Pramanik, Sanjay M Sonune, Sanjay M Chawhan |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 9, Iss 11, Pp BC01-BC03 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2015/15345.6707 |
| Popis: | Background: Paraoxonase 1 (PON1) is an enzyme associated with High density lipoprotein (HDL) in blood and it is considered to have antioxidant and antiatherogenic properties. PON1 plays an important role in protecting HDL and especially low density lipoprotein (LDL) from oxidative modification by hydrolyzing lipid peroxides which are known to be associated with many vascular diseases including atherosclerosis and ischemic stroke. Aim: The aim of the study was to evaluate and correlate serum paraoxonase (PON1) and arylesterase (ARE) activities as well as lipid profile levels in patients with ischemic stroke. Materials and Methods: The study population was comprised of 50 ischemic stroke patients and 50 healthy controls. The serum PON1 and ARE activities were measured spectrophotometrically by using paraoxon and phenylacetate as substrate respectively by Eckerson method. Serum lipid was measured using routine biochemical method. Results: The normality of the distribution of the parameters are assessed by Shapiro-Wilk test. Two sample t-test is applied for hypothesis testing. The serum PONI and arylesterase ARE decreased significantly in ischemic stroke patients (p |
| Databáze: | Directory of Open Access Journals |
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