Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination

Autor: He-Yuan Bai, Fu-Xin Tan, Tuan-Qing Liu, Guo-Dong Zhu, Jin-Miao Tian, Tong-Mei Ding, Zhi-Min Chen, Shu-Yu Zhang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10858-x
Popis: Atropisomers with a chiral C-N axis are useful for natural products synthesis and as ligands in asymmetric catalysis. Here, the authors reportt a π-π interaction and dual H-bond concerted control strategy in enantioselective C-H amination affording configurationally stable N-C atropisomers.
Databáze: Directory of Open Access Journals