Diaphragm dysfunction as a potential determinant of dyspnea on exertion in patients 1 year after COVID-19-related ARDS

Autor: Jens Spiesshoefer, Janina Friedrich, Binaya Regmi, Jonathan Geppert, Benedikt Jörn, Alexander Kersten, Alberto Giannoni, Matthias Boentert, Gernot Marx, Nikolaus Marx, Ayham Daher, Michael Dreher
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Respiratory Research, Vol 23, Iss 1, Pp 1-6 (2022)
Druh dokumentu: article
ISSN: 1465-993X
DOI: 10.1186/s12931-022-02100-y
Popis: Abstract Some COVID-19 patients experience dyspnea without objective impairment of pulmonary or cardiac function. This study determined diaphragm function and its central voluntary activation as a potential correlate with exertional dyspnea after COVID-19 acute respiratory distress syndrome (ARDS) in ten patients and matched controls. One year post discharge, both pulmonary function tests and echocardiography were normal. However, six patients with persisting dyspnea on exertion showed impaired volitional diaphragm function and control based on ultrasound, magnetic stimulation and balloon catheter-based recordings. Diaphragm dysfunction with impaired voluntary activation can be present 1 year after severe COVID-19 ARDS and may relate to exertional dyspnea. This prospective case–control study was registered under the trial registration number NCT04854863 April, 22 2021
Databáze: Directory of Open Access Journals
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