Intracellular Host Restriction of Hepatitis B Virus Replication

Autor:	Prakriti Sinha, Chloe L. Thio, Ashwin Balagopal
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	hepatitis B virus host restriction factors viral transcription cccDNA transcriptional silencing Smc5/6 Microbiology QR1-502
Zdroj:	Viruses, Vol 16, Iss 5, p 764 (2024)
Druh dokumentu:	article
ISSN:	1999-4915
DOI:	10.3390/v16050764
Popis:	The hepatitis B virus (HBV) infects hepatocytes and hijacks host cellular mechanisms for its replication. Host proteins can be frontline effectors of the cell’s defense and restrict viral replication by impeding multiple steps during its intracellular lifecycle. This review summarizes many of the well-described restriction factors, their mechanisms of restriction, and counteractive measures of HBV, with a special focus on viral transcription. We discuss some of the limitations and knowledge gaps about the restriction factors, highlighting how these factors may be harnessed to facilitate therapeutic strategies against HBV.
Databáze:	Directory of Open Access Journals
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