Expression of gonadotropin-releasing hormone receptor type-II correlates with proliferation activity in tissue microarray of rare ovarian tumor
| Autor: | Kiky Martha Ariesaka, Ardhanu Kusumanto, Muhammad Ary Zucha, Nungki Anggorowati, Agil Wahyu Wicaksono, Moch Yunus, Erianto Fanani, Moh Mirza Nuryady |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Indonesian Journal of Medical Laboratory Science and Technology, Vol 6, Iss 2 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2684-6748 2656-9825 |
| DOI: | 10.33086/ijmlst.v6i2.6034 |
| Popis: | Activation of Gonadotropin-Releasing Hormone type II Receptors (GnRHR-II) exhibits antiproliferative activity. GnRHR-II is not only expressed exclusively in the pituitary, but also in a variety of tumors. To date, the clinical relevance of GnRHR-II in ovarian tumors is unclear. In addition, there is a lack of literature addressing GnRHR-II in ovarian tumors, especially rare types. This study was conducted to investigare the correlation between GnRHR-II expression with clinicopathology and proliferative activity of rare ovarian tumors. The purpose of this study was an analytic observational study with a cross-sectional design that utilized 18 ovarian tumor samples on tissue microarray (TMA). The expression of GnRHR-II and Ki67 was assessed using immunohistochemical staining (IHC) and observed using the IHC profiler plugin ImageJ software to obtain their respective H-scores. The data was analyzed using independent t-test, ANOVA, Pearson's test, and Fisher's exact test based on data types. The value of p |
| Databáze: | Directory of Open Access Journals |
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