| Autor: |
Leandro Galvis, Ángel Y. Sánchez, Leonardo F. Jurado, Martha I. Murcia |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 1, Pp 7-16 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
0120-4157 |
| DOI: |
10.7705/biomedica.v38i0.3273 |
| Popis: |
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn’s disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections. We report the case of a 68-year-old man with Crohn’s disease, who developed disseminated tuberculosis due to anti-TNF-α immunosuppressive therapy. The diagnosis was based on the histopathological findings and molecular biology assays. We discuss the clinical presentation and workup of this case, and we present a comparative analysis of tuberculosis cases associated with anti-TNF-α reported in Colombia during the last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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