Unique features of transcription termination and initiation at closely spaced tandem human genes

Autor: Noa Nissani, Igor Ulitsky
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Molecular Systems Biology, Vol 18, Iss 4, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 1744-4292
DOI: 10.15252/msb.202110682
Popis: Abstract The synthesis of RNA polymerase II (Pol2) products, which include messenger RNAs or long noncoding RNAs, culminates in transcription termination. How the transcriptional termination of a gene impacts the activity of promoters found immediately downstream of it, and which can be subject to potential transcriptional interference, remains largely unknown. We examined in an unbiased manner the features of the intergenic regions between pairs of ‘tandem genes’—closely spaced (
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje