Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process
Autor: | Xiyan Li, Chuangji Li, Mengxi Su, Xinyi Zhong, Yihan Xing, Zhengjie Shan, Shoucheng Chen, Xingchen Liu, Xiayi Wu, Quan Liu, Ye Li, Shiyu Wu, Zhuofan Chen |
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Jazyk: | angličtina |
Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Science and Technology of Advanced Materials, Vol 24, Iss 1 (2023) |
Druh dokumentu: | article |
ISSN: | 14686996 1878-5514 1468-6996 |
DOI: | 10.1080/14686996.2023.2186690 |
Popis: | ABSTRACTBiogenic collagen membranes (BCM) have been widely used in guided bone regeneration (GBR) owing to their biodegradability during tissue integration. However, their relatively high degradation rate and lack of pro-osteogenic properties limit their clinical outcomes. It is of great importance to endow BCM with tailored degradation as well as pro-osteogenic properties. In this study, a fluoride-modified polymer-induced liquid precursor (PILP) based biomineralization strategy was used to convert the collagen membrane from an organic phase to an apatite-based inorganic phase, thus achieving enhanced anti-degradation performance as well as osteogenesis. As a result, three phases of collagen membranes were prepared. The original BCM in the organic phase induced the mildest inflammatory response and was mostly degraded after 4 weeks. The organic-inorganic mixture phase of the collagen membrane evoked a prominent inflammatory response owing to the fluoride-containing amorphous calcium phosphate (F-ACP) nanoparticles, resulting in active angiogenesis and fibrous encapsulation, whereas the inorganic phase induced a mild inflammatory response and degraded the least owing to the transition of F-ACP particles into calcium phosphate with high crystallinity. Effective control of ACP is key to building novel apatite-based barrier membranes. The current results may pave the way for the development of advanced apatite-based membranes with enhanced barrier performances. |
Databáze: | Directory of Open Access Journals |
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