The cytomorphological spectrum of Hashimoto thyroiditis and its correlation with serological parameters: A study in the coastal region

Autor: Nibedita Sahoo, Sujata Naik, Pranita Mohanty, Pradeep N Sahoo, Prateek Das
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Dr. NTR University of Health Sciences, Vol 9, Iss 1, Pp 25-31 (2020)
Druh dokumentu: article
ISSN: 2277-8632
DOI: 10.4103/JDRNTRUHS.JDRNTRUHS_125_19
Popis: Objective: To analyse the detailed cytomorphological spectrum in Hashimoto thyroiditis (HT), cytological grading and its significance with the hormonal and antibody status Methods: This is both a prospective and retrospective study of 102 cases of HT in a tertiary care institute of the eastern part of India. Detailed cytological parameters were observed, graded and correlated with the serological parameters. Results: The majority of patients were females with a younger age group (21–30 years) and diffuse thyromegaly was the common presentation. A good number of cases showed neutrophilic infiltration, background colloid and follicular hyperplasia. Among the cytological parameters, Hurthle cell change was correlated with hypothyroidism (P < 0.05) but there was no significant correlation with the anti-TPO antibody. Statistical correlation of different cytological grades with the anti-TPO antibody was significant (P < 0.05), however the thyroid hormone profile with cytological grade and TPO level were not significant (P > 0.05). Conclusion: A younger age of presentation in a coastal area with iodine sufficiency and supplementation needs further epidemiological studies. Fine-needle aspiration cytology is superior to other sophisticated methods in diagnosing HT, even in seronegative cases. A good number of cases displaying folliculolysis by neutrophils needs to be corroborated by larger studies. One should be vigilant while examining slides to rule out associated malignancy.
Databáze: Directory of Open Access Journals
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