Single center experience on the production of fluorine-18 radiopharmaceuticals using a 7.5 MeV cyclotron: capabilities and challenges

Autor: Andreas Fesas, Mohammad Reza Pourkhessalian, Alexis Vrachimis
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: SN Applied Sciences, Vol 2, Iss 5, Pp 1-6 (2020)
Druh dokumentu: article
ISSN: 2523-3963
2523-3971
DOI: 10.1007/s42452-020-2695-2
Popis: Abstract A plethora of cyclotron options have been developed to fulfil the demands of nuclear medicine industries in PET and SPECT radioisotopes. As a remote site, the difficulties of transporting fluorine 18 radiopharmaceuticals for PET examinations were overcome by the installation of a 7.5 MeV cyclotron for in-house production. The addition of a third-party synthesis module enabled the synthesis of 7 additional radiotracers according to a ‘’dose on demand’’ principle. Radiochemical yield is considered the primary factor in producing sufficient activity for a single patient dose, since low energy cyclotrons can only offer low initial activities. We hereby report the average radiochemical yields, synthesis times and doses per production for [18F]FDG, [18F]PSMA-1007, [18F]DOPA, [18F]FET, [18F]FLT, [18F]FMISO, [18F]Choline and [18F]FES using a BG75 cyclotron and a Neptis Mosaic-RS. Additionally, the presence of radionuclidic impurities in the final product was examined.
Databáze: Directory of Open Access Journals
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