Change of Tumor Cell Multiple Drug Resistance Inhibitory Activity of Oligomycins in Complexes with Lithium and Zinc

Autor: M. V. Bibikova, A. N. Danilenko, A. V. Katlinsky, A. F. Korystova, L. N. Kublik, M. Kh. Levitman, V. V. Shaposhnikova, Yu. N. Korystov
Jazyk: ruština
Rok vydání: 2020
Předmět:
Zdroj: Антибиотики и Химиотерапия, Vol 60, Iss 11-12, Pp 9-14 (2020)
Druh dokumentu: article
ISSN: 0235-2990
Popis: Oligomycins and their complexes with lithium and zinc were shown to be less active vs. cyclosporin A in inhibition of transport proteins responsible for multiple drug resistance of lymphoid leukosis P388VR cells, while certain oligomycin complexes were tens or hundreds times more active than cyclosporin A by inhibition of transport proteins in another type of tumor cells, i.e. human larynx cancer Hep-2, that makes possible the use of the oligomycins complexes with lithium and zinc for inhibition of multiple drug resistance of certain tumor types.
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