Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells

Autor: Oyinbo Charles A., Igbigbi Patrick S., Avwioro Godwin O.
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Folia Medica, Vol 58, Iss 4, Pp 241-249 (2016)
Druh dokumentu: article
ISSN: 1314-2143
DOI: 10.1515/folmed-2016-0034
Popis: Background: Alcohol-induced cerebellar neurodegeneration is a neuroadaptation that is associated with chronic alcohol abuse. Conventional drugs have been largely unsatisfactory in preventing neurodegeneration. Yet, multimodal neuro-protective therapeutic agents have been hypothesised to have high therapeutic potential for the treatment of CNS conditions; there is yet a dilemma of how this would be achieved. Contrarily, medicinal botanicals are naturally multimodal in their mechanism of action.
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