Novel Therapeutic Options for Solitary Fibrous Tumor: Antiangiogenic Therapy and Beyond

Autor:	Axel de Bernardi, Armelle Dufresne, Florence Mishellany, Jean-Yves Blay, Isabelle Ray-Coquard, Mehdi Brahmi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	SFT rare sarcoma antiangiogenics immune-checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancers, Vol 14, Iss 4, p 1064 (2022)
Druh dokumentu:	article
ISSN:	2072-6694
DOI:	10.3390/cancers14041064
Popis:	SFT is an ultrarare mesenchymal ubiquitous tumor, with an incidence rate NAB2–STAT6 oncogenic fusion, which is the pathognomonic hallmark of SFT, is supposedly involved in the overexpression of vascular endothelial growth factor (VEGF). These specific biological features encouraged the successful assessment of antiangiogenic drugs. Overall, antiangiogenic therapies showed a significant activity toward SFT in the advanced/metastatic setting. Nevertheless, these promising results warrant additional investigation to be validated, including randomized phase III trials and biological translational analysis, to understand and predict mechanisms of efficacy and resistance. While the therapeutic potential of immunotherapy remains elusive, the use of antiangiogenics as first-line treatment should be considered.
Databáze:	Directory of Open Access Journals
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