Allogeneic islet transplantation with monitoring of islet‐specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report

Autor: Daisuke Chujo, Toshiaki Kurokawa, Akitsu Kawabe, Nobuyuki Takahashi, Fuyuki Inagaki, Koya Shinohara, Shotaro Hagiwara, Yoshihiro Edamoto, Norio Ohmagari, Fumihiko Hinoshita, Tsuyoshi Tajima, Hiroshi Kajio, Hiroshi Ohtsu, Nobuyuki Takemura, Shinichi Matsumoto, Masayuki Shimoda
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 13, Iss 4, Pp 741-745 (2022)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13715
Popis: Abstract Here, we report a case of allogeneic islet transplantation in Japan. A 48‐year‐old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient’s T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen‐specific CD8+ T‐cell responses before the deterioration of pancreatic β‐cell function, indicating the possibility of the non‐invasive detection of pancreatic β‐cell damage due to recurrent autoimmunity.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje