| Autor: |
Prashanta Silwal, Jin Kyung Kim, Sang Min Jeon, June-Young Lee, Young Jae Kim, Yi Sak Kim, Yeji Seo, Jihye Kim, Soo Yeon Kim, Min Joung Lee, Jun Young Heo, Mi-Ja Jung, Hyun Sik Kim, Dong-Wook Hyun, Jeong Eun Han, Jake Whang, Yang Hoon Huh, Sang-Hee Lee, Won Do Heo, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2399-3642 |
| DOI: |
10.1038/s42003-021-02073-6 |
| Popis: |
Silwal, Kim et al. show that mitofusin-2 (MFN2), a mitochondrial fusion protein, promotes innate host defense through coordinated orchestration of immunometabolism and xenophagy via HIF-1α in macrophages during bacterial infection. This study provides insights into how mitochondria-shaping protein is involved in host defense against intracellular bacterial infection. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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