Model-based Identification of Some Conditions Leading to Glycolytic Oscillations in E. coli Cells

Autor:	G. Maria, M. Mihalachi, C. Luminita Gijiu
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	reduced dynamic model glycolysis Escherichia coli oscillation occurrence in silico determination of glycolytic oscillation conditions Chemical engineering TP155-156
Zdroj:	Chemical and Biochemical Engineering Quarterly, Vol 32, Iss 4, Pp 523-533 (2019)
Druh dokumentu:	article
ISSN:	0352-9568 1846-5153
DOI:	10.15255/CABEQ.2017.1241
Popis:	Autonomous oscillations of glycolytic intermediate concentrations reflect the dynamics of the control and regulation of this major catabolic pathway, and this phenomenon has been reported in a broad range of bacteria. Understanding glycolytic oscillations might therefore prove crucial for the general understanding of the regulation of cell metabolism with immediate practical applications, allowing in silico design of modified cells with desirable ‘motifs’ of practical applications in the biosynthesis industry, environmental engineering, and medicine. By using a kinetic model from literature, this paper is aiming at in silico (model-based) identification of some conditions leading to the occurrence of stable glycolytic oscillations in the E. coli cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/241378ca936c404d8e370aa7e2dc8057 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF