Osteogenic potential of different chalcones in an in vivo model: A preliminary study.
| Autor: | Xana Raquel Ortolan, Telmo José Mezadri, David Rivero Tames, Rogério Corrêa, Fátima Campos-Buzzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Oral Research, Vol 6, Iss 8, Pp 209-215 (2017) |
| Druh dokumentu: | article |
| ISSN: | 0719-2460 0719-2479 |
| DOI: | 10.17126/joralres.2017.059 |
| Popis: | Aim. To evaluate the osteogenic potential of chalcones using the rat critical size calvarial defect. Methods. The chalcones were synthesized from acetophenone following the Claisen-Schmidt aldol condensation method by varying the substituted benzaldehydes (3,4-Cl; 4-Cl; 4-CH3; 4-OCH3, H). The five chalcone molecules were evaluated in three concentrations (1%, 5% and 10%) in comparison to control and vehicle (Vaseline) groups. The results of the remaining wound areas were calculated statistically by the ANOVA method followed by the Student-Newman-Keuls test and the histological sections were analyzed qualitatively by light microscopy. Results. All molecules at 10% concentration showed significant bone closure compared to the control, vehicle and chalcone groups at 1% concentration (p |
| Databáze: | Directory of Open Access Journals |
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