Applications of type I and II collagen in osteochondral tissue engineering: Respective features and future perspectives

Autor: Ruoyu Huang, Xiaolian Niu, Xueying Li, Xiaoming Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Medicine in Novel Technology and Devices, Vol 24, Iss , Pp 100328- (2024)
Druh dokumentu: article
ISSN: 2590-0935
DOI: 10.1016/j.medntd.2024.100328
Popis: At present, osteoarthritis stands as one of the most prevalent degenerative musculoskeletal diseases globally. The inherent lack of self-healing capacity in articular cartilage presents a considerable obstacle in treating osteoarthritis. Tissue engineering emerged as a promising strategy for the regeneration of osteochondral defects. Collagen, a primary component of bone and cartilage, stands out as a widely utilized natural material in osteochondral tissue engineering. Among various collagen types, Type I and type II collagen are notably prominent in this field. This review initially summarizes the advantageous and disadvantageous properties of type I/II collagen in osteochondral tissue engineering, proceeds to introduce their applications in this context, and concludes with a prospective outlook on the future development of type I/II collagen's applications.
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