Estimates of the global burden of Congenital Rubella Syndrome, 1996-2019

Autor: Emilia Vynnycky, Jennifer K. Knapp, Timos Papadopoulos, Felicity T. Cutts, Masahiko Hachiya, Shinsuke Miyano, Susan E. Reef
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 137, Iss , Pp 149-156 (2023)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2023.09.003
Popis: Objectives: Many countries introduced rubella-containing vaccination (RCV) after 2011, following changes in recommended World Health Organization (WHO) vaccination strategies and external support. We evaluated the impact of these introductions. Methods: We estimated the country-specific, region-specific, and global Congenital Rubella Syndrome (CRS) incidence during 1996-2019 using mathematical modeling, including routine and campaign vaccination coverage and seroprevalence data. Results: In 2019, WHO African and Eastern Mediterranean regions had the highest estimated CRS incidence (64 [95% confidence intervals (CI): 24-123] and 27 [95% CI: 4-67] per 100,000 live births respectively), where nearly half of births occur in countries that have introduced RCV. Other regions, where >95% of births occurred in countries that had introduced RCV, had a low estimated CRS incidence (
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