| Autor: |
Sivaprakasam T. Selvavinayagam, Sathish Sankar, Yean K. Yong, Amudhan Murugesan, Suvaiyarasan Suvaithenamudhan, Kannan Hemashree, Manivannan Rajeshkumar, Anandhazhvar Kumaresan, Ramendra P. Pandey, Saravanan Shanmugam, Parthiban Arthydevi, Masilamani Senthil Kumar, Natarajan Gopalan, Meganathan Kannan, Narayanaiah Cheedarla, Hong Y. Tan, Ying Zhang, Marie Larsson, Pachamuthu Balakrishnan, Vijayakumar Velu, Siddappa N. Byrareddy, Esaki M. Shankar, Sivadoss Raju |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-68678-z |
| Popis: |
Abstract In December 2023, we observed a notable shift in the COVID-19 landscape, when JN.1 omicron emerged as the predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of interest. Whole genome sequencing was performed on SARS-CoV-2 positive clinical specimens, followed by sequence analysis. Mutations within the spike protein sequences were analysed and compared with the previously reported lineages and sub-lineages, to identify the potential impact of the unique mutations on protein structure and possible alterations in the functionality. Several unique and dynamic mutations were identified herein. Molecular docking analysis showed changes in the binding affinity, and key interacting residues of wild-type and mutated structures with key host cell receptors of SARS-CoV-2 entry viz., ACE2, CD147, CD209L and AXL. Our data provides key insights on the emergence of newer variants and highlights the necessity for robust and sustained global genomic surveillance of SARS-CoV-2. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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