Lineage-specific partitions in archaeal transcription

Autor: Richard M. R. Coulson, Nathalie Touboul, Christos A. Ouzounis
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Zdroj: Archaea, Vol 2, Iss 2, Pp 117-125 (2006)
Druh dokumentu: article
ISSN: 1472-3646
1472-3654
DOI: 10.1155/2006/629868
Popis: The phylogenetic distribution of the components comprising the transcriptional machinery in the crenarchaeal and euryarchaeal lineages of the Archaea was analyzed in a systematic manner by genome-wide profiling of transcription complements in fifteen complete archaeal genome sequences. Initially, a reference set of transcription-associated proteins (TAPs) consisting of sequences functioning in all aspects of the transcriptional process, and originating from the three domains of life, was used to query the genomes. TAP-families were detected by sequence clustering of the TAPs and their archaeal homologues, and through extensive database searching, these families were assigned a function. The phylogenetic origins of archaeal genes matching hidden Markov model profiles of protein domains associated with transcription, and those encoding the TAP-homologues, showed there is extensive lineage-specificity of proteins that function as regulators of transcription: most of these sequences are present solely in the Euryarchaeota, with nearly all of them homologous to bacterial DNA-binding proteins. Strikingly, the hidden Markov model profile searches revealed that archaeal chromatin and histone-modifying enzymes also display extensive taxon-restrictedness, both across and within the two phyla.
Databáze: Directory of Open Access Journals
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