Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive

Autor: Stephanie Gamez, Duverney Chaverra-Rodriguez, Anna Buchman, Nikolay P. Kandul, Stelia C. Mendez-Sanchez, Jared B. Bennett, Héctor M. Sánchez C., Ting Yang, Igor Antoshechkin, Jonny E. Duque, Philippos A. Papathanos, John M. Marshall, Omar S. Akbari
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27333-1
Popis: CRISPR-based engineering can be used to bias sex ratios. Here the authors develop a transgenic line of Drosophila melanogaster expressing Cas9 from the Y chromosome and functionally characterize the utility of this strain for both sex selection and gene drive.
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