| Autor: |
Roman O. Kowalchuk, Grant M. Spears, Lindsay K. Morris, Dawn Owen, Harry H. Yoon, Krishan Jethwa, Michael D. Chuong, Matthew J. Ferris, Michael G. Haddock, Christopher L. Hallemeier, Dennis Wigle, Steven H. Lin, Kenneth W. Merrell |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2023.1081024 |
| Popis: |
Purpose/objectivePostoperative toxicity for esophageal cancer impacts patient quality of life and potentially overall survival (OS). We studied whether patient and toxicity parameters post-chemoradiation therapy predict for post-surgical cardiopulmonary total toxicity burden (CPTTB) and whether CPTTB was associated with short and long-term outcomes.Materials/methodsPatients had biopsy-proven esophageal cancer treated with neoadjuvant chemoradiation and esophagectomy. CPTTB was derived from total perioperative toxicity burden (Lin et al. JCO 2020). To develop a CPTTB risk score predictive for major CPTTB, recursive partitioning analysis was used.ResultsFrom 3 institutions, 571 patients were included. Patients were treated with 3D (37%), IMRT (44%), and proton therapy (19%). 61 patients had major CPTTB (score ≥ 70). Increasing CPTTB was predictive of decreased OS (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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