Effect of long term administration of tamoxifen on memory in male rat
| Autor: | Asle-Rousta M |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی گرگان, Vol 18, Iss 2, Pp 54-60 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1562-4765 2008-4080 |
| Popis: | Background and Objective: Tamoxifen is one of the selective estrogen receptor modulators that exerts estrogen / anti-estrogen effects in various tissues. This study was done to evaluate the effect of chronic administration of tamoxifen on spatial memory and passive avoidance task in adult male Wistar rats. Methods: In this experimental study, 48 adult male Wistar rats were randomly divided into control, sham and tamoxifen groups. Animals in sham and tamoxifen groups were received tamoxifen solution and tamoxifen (400mg/kg/day) orally for 35 consecutive days. At the end of treatment, spatial learning and memory of animals was assessed using the Morris water maze task and passive avoidance memory was examined using the shuttle box. Results: The time spent and distance moved to reach the platform, significantly increased in tamoxifen group compared to controls (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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