| Autor: |
Amelia Guadalupe-Grau, Francisco Germán Rodríguez-González, Jesús Gustavo Ponce-González, Cecilia Dorado, Hugo Olmedillas, Teresa Fuentes, Jorge Pérez-Gómez, Joaquín Sanchís-Moysi, Bonifacio Nicolás Díaz-Chico, José A L Calbet |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 5, Iss 7, p e11529 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0011529 |
| Popis: |
BackgroundTo determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men.Methodology/principal findingsWhole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalcin and free testosterone (ELISA) were determined in 282 healthy men (28.6+/-7.6 years). Individuals were grouped as CAG short (CAG(S)) if harboring repeat lengths of < or = 21 or CAG long (CAG(L)) if CAG > 21, and GGN was considered short (GGN(S)) or long (GGN(L)) if GGN < or = 23 or > 23. There was an inverse association between logarithm of CAG and GGN length and Ward's Triangle BMC (r = -0.15 and -0.15, PConclusionAR polymorphisms have an influence on BMC and BMD in healthy adult humans, which cannot be explained through effects in osteoblastic activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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