| Autor: |
Struan F A Grant, Mingyao Li, Jonathan P Bradfield, Cecilia E Kim, Kiran Annaiah, Erin Santa, Joseph T Glessner, Tracy Casalunovo, Edward C Frackelton, F George Otieno, Julie L Shaner, Ryan M Smith, Marcin Imielinski, Andrew W Eckert, Rosetta M Chiavacci, Robert I Berkowitz, Hakon Hakonarson |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 3, Iss 3, p e1746 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0001746 |
| Popis: |
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. We examined the effects of two perfect surrogates for this SNP plus 11 other SNPs at this locus with respect to our childhood obesity cohort, consisting of both Caucasians and African Americans (AA). Utilizing data from our ongoing GWA study in our cohort of 418 Caucasian obese children (BMI>or=95th percentile), 2,270 Caucasian controls (BMI |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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