Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer

Autor:	Chad J. Creighton, Flora Zhang, Yiqun Zhang, Patricia Castro, Rong Hu, Md Islam, Somiranjan Ghosh, Michael Ittmann, Bernard Kwabi-Addo
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	clinically localized prostate cancer dna methylation gene expression genome-wide profiling cpg methylation african american men Genetics QH426-470
Zdroj:	Epigenetics, Vol 18, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	1559-2294 1559-2308 15592294
DOI:	10.1080/15592294.2023.2180585
Popis:	African American (AA) men have the highest incidence and mortality rate from Prostate cancer (PCa) than any other racial/ethnic group. To date, PCa genomic studies have largely under-represented tumour samples from AA men. We measured genome-wide DNA methylation in benign and tumor prostate tissues from AA men using the Illumina Infunium 850 K EPIC array. mRNA expression database from a subset of the AA biospecimen were used to assess correlation of transcriptome and methylation datasets. Genome-wide methylation analysis identified 11,460 probes that were significant (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/23d25d808dcd449d914fff78cc1dda88 Zobrazit plný text záznamu View record in DOAJ