Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy

Autor: Eduardo Morato de OLIVEIRA, Rafael Soares GUIEIRO, Bárbara Lima CRUZ, Maria Cássia Ferreira de AGUIAR, Janine Mayra da SILVA, Tarcília Aparecida SILVA, Patrícia Carlos CALDEIRA
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Brazilian Oral Research, Vol 35 (2021)
Druh dokumentu: article
ISSN: 1807-3107
DOI: 10.1590/1807-3107bor-2021.vol35.0079
Popis: Abstract Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared with non-irradiated individuals. Total unstimulated saliva was collected for ELISA assay analysis of receptor activator for nuclear factor κ B (RANK) and its ligand (RANK-L), osteoprotegerin, matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, and epidermal growth factor. Statistics were performed, and revealed that salivary RANK (p = 0.0304), RANK-L (p = 0.0005), matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2 (p = 0.0067), vascular endothelial growth factor (p = 0.0060), and epidermal growth factor (p < 0.0001) were reduced in patients, compared with the control group. Osteoprotegerin did not differ between the groups (p = 0.3765). Salivary biomarkers did not differ according to radiotherapy completion time (p > 0.05). In conclusion, the lower output of the salivary molecules – essential for bone remodeling and tissue repair – may disrupt tissue homeostasis and play a role in the pathogenesis of the radiotherapy-induced deleterious effects in the oral cavity.
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