Platelet function and Isoprostane biology. Should Isoprostanes be the newest member of the Orphan-ligand family?
| Autor: | Khasawneh Fadi T, Ting Harold J |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Journal of Biomedical Science, Vol 17, Iss 1, p 24 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1423-0127 1021-7770 |
| DOI: | 10.1186/1423-0127-17-24 |
| Popis: | Abstract While there have been many reports investigating the biological activity and signaling mechanisms of isoprostanes, their role in biology, particularly in platelets, appears to still be underestimated. Moreover, whether these lipids have their own receptors is still debated, despite multiple reports that discrete receptors for isporpstanes do exist on platelets, vascular tissues, amongst others. This paper provides a review of the important literature of isoprostanes and provides reasoning that isoprostanes should be classified as orphan ligands until their receptor(s) is/are identified. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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