The paternal genome and the health of the assisted reproductive technology child
| Autor: | Sheena EM Lewis, Kishlay Kumar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
gene regulation
Musashi Musashi-1 Musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation cell fate cell stress importin karyopherin nucleocytoplasmic transport spermatid spermatocyte artificial insemination biomarker fertility fertilization flow cytometry infertility nanotechnology oocyte activation Postacrosomal Sheath WWI Domain Binding Protein sperm SPTRX3 thioredoxin ubiquitin ATP binding cassette transporters albumin high-density lipoprotein lipid rafts membrane fluidity membrane microdomains membrane packing oxysterols reverse cholesterol transport sterol transporters egg heat shock protein A2 molecular chaperone sperm-egg interactions dehydrogenases oxidases peroxiredoxins reactive oxygen species spermatozoa thiols thioredoxins antigen-presenting cells autoimmunity dendritic cells epididymis macrophages peripheral tolerance sperm maturation genomics male infertility proteomics sperm chromatin sperm epigenetics sperm DNA damage paternal genome offspring Diseases of the genitourinary system. Urology RC870-923 |
| Zdroj: | Asian Journal of Andrology, Vol 17, Iss 4, Pp 616-622 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1008-682X 1745-7262 |
| DOI: | 10.4103/1008-682X.153301 |
| Popis: | As a number of children born by assisted reproductive technology (ART) are increasing each year across the developed world, the health of such offspring is a matter of public concern. Does the integrity of the paternal genome impact on offspring health? In societal terms, as birth rates fall, and the Western population become unsustainable, do the benefits outweigh the costs of creating and providing for this ART conceived subpopulation? There are little data to date to answer these questions. The long-term health of such children has largely been ignored, and success measured only by early (prebirth) outcomes such as embryo quality or pregnancy. However, there are powerful paradigms such as ageing and smoking that give vital clues as to the potential impact of unhealthy spermatozoa on disease risk, mental and physical health, fertility and mortality of these offspring. |
| Databáze: | Directory of Open Access Journals |
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