Urinary Uric Acid and Creatinine Ratio as a Marker of Perinatal Asphyxia
| Autor: | Kartika Gulati, Shree Vishnoi, Sandeep Choudhary, Rakesh Jora |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Iranian Journal of Neonatology, Vol 13, Iss 1, Pp 18-24 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2251-7510 2322-2158 |
| DOI: | 10.22038/ijn.2021.55457.2056 |
| Popis: | Background: Prediction of the outcome of perinatal asphyxia (PA) is important but formidable. Apgar score has a limited role in predicting the outcome. Urinary uric acid and creatinine ratio (UA/Cr) is an early, noninvasive, and cheap biomarker of PA which may predict its morbidity. This study aimed to determine the urinary UA/Cr in neonates with PA, compare it with UA/Cr in non-asphyxiated neonates, and derive the optimum cut-off value of this ratio to label PA.Methods: This observational cross-sectional study was carried out on 100 term neonates appropriate for gestational age (AGA) with PA (cases) and 100 non-asphyxiated term AGA babies (controls). Urine samples were collected within 24 h of life; moreover, uric acid and creatinine levels were determined by an auto-analyzer.Results: The mean urinary UA/Cr ratio was significantly higher in the cases, compared to the controls (3.41±0.68 vs. 1.99±0.23) (P2.5 with sensitivity, specificity, positive predictive value, and negative predictive value of 98%. Urinary UA/Cr ratio and cord blood pH were significantly correlated with each other (correlation coefficient r=-0.8951, P |
| Databáze: | Directory of Open Access Journals |
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