Reasons for Failure of Antifungal-lock Therapy with Caspofungin: Need for Higher Concentrations

Autor:	Rana İşgüder, Gökhan Ceylan, Özlem Sandal, Ferhat Sarı, Gamze Gülfidan, Bengü Demirağ, Hasan Ağın, İlker Devrim
Jazyk:	English<br />Turkish
Rok vydání:	2017
Předmět:	Antifungal kilit tekniği Candida türleri kaspofungin kateter Medicine Pediatrics RJ1-570 Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Journal of Pediatric Emergency and Intensive Care Medicine, Vol 4, Iss 1, Pp 30-32 (2017)
Druh dokumentu:	article
ISSN:	2146-2399 2148-7332
DOI:	10.4274/cayd.83792
Popis:	Antifungal-lock therapy (AfLT) has arrived as an investigational approach for preventing catheter removal with limited clinical evidence of its efficiency. The principle of AfLT consists of catheter lumen replenishment by a selected antimicrobial agent and then locking it for an alternative treatment to eradicate the microbes embedded in endoluminal biofilms. Herein, we report a pediatric hematology-oncology patient with Candida parapsilosis-related central venous access device infection in which catheter removal was performed despite the systemic and intraluminal caspofungin treatment. For now, we recommend higher doses of caspofungin for AfLT especially in Candida parapsilosis-related catheter infections.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/23b2d39a1b9f415baa6fa08cee47d638 Zobrazit plný text záznamu View record in DOAJ