Can Ursodeoxycholic Acid Prevent SARS-CoV-2 Infection or Reduce the COVID-19 Severity? Current Knowledge and Unresolved Issues
| Autor: | Shida Pan, Yang Zhang, Fanping Meng, Fu-Sheng Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Medicine, Vol 3, Iss 3, Pp 114-119 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0025-7974 1536-5964 00000000 |
| DOI: | 10.1097/ID9.0000000000000092 |
| Popis: | Abstract. A recent study revealed that the inhibition of the farnesoid X receptor using ursodeoxycholic acid (UDCA) significantly reduces angiotensin-converting enzyme 2 (ACE2) expression. Therefore, considerable attention has been paid to the use of UDCA to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and reduce the severity of the disease. This review comprehensively summarizes the role of ACE2 in SARS-CoV-2 infection and the potential role and mechanisms of UDCA in the prevention of SARS-CoV-2 infection or reinfection. It also discusses unresolved issues and the potential use of UDCA in the treatment of patients with coronavirus disease. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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