| Autor: |
A. Yamanami-Irioka, T. Uchihara, T. Endo, T. Irioka, M. Watanabe, M. Kitagawa, H. Mizusawa |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Case Reports in Neurology, Vol 3, Iss 3, Pp 242-247 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1662-680X |
| DOI: |
10.1159/000331859 |
| Popis: |
A 68-year-old man with a clinical diagnosis of Alzheimer’s disease (AD) later developed amyotrophic lateral sclerosis (ALS), which was confirmed at autopsy at age 72 years. Because neuronal loss and AD-type pathologies (Braak stage II for neurofibrillary tangles) were scant, TDP-43-positive intracytoplasmic inclusions in hippocampal dentate granular cells and in neurons in the subiculum and amygdala, even though small in amount, may represent the earliest lesions of ALS-related dementia and could be the cause of dementia in this patient. Although the persistent elevation of creatine kinase from the onset could be a pointer to the presence of motor involvement, more accurate characterization of dementia, which may differentiate ALS-related dementia and AD, is necessary. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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