Adolescents with type 1 diabetes can achieve glycemic targets on intensive insulin therapy without excessive weight gain

Autor: Alexandra L. Marlow, Bruce R. King, Helen T. Phelan, Carmel E. Smart
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Endocrinology, Diabetes & Metabolism, Vol 5, Iss 4, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2398-9238
DOI: 10.1002/edm2.352
Popis: Abstract Introduction The aim of this study was to compare glycemic control and body mass index standard deviation score (BMI‐SDS) before and after implementation of intensive insulin therapy using multiple daily injection (MDI) or continuous subcutaneous insulin infusion (CSII) in adolescents with type 1 diabetes (T1D) attending a large multidisciplinary paediatric diabetes clinic in Australia. Methods Prospective data were collected for cross‐sectional comparison of youth aged 10.0–17.9 years (n = 669) from routine follow‐up visits to the diabetes clinic in 2004, 2010, and 2016. Outcome measures included HbA1c; BMI‐SDS; and insulin regimen. Results BMI‐SDS remained stable between 2004 to 2016 in the 10–13 and 14–17 year age group (0.7 vs. 0.5, p = .12 and 0.7 vs. 0.7, p = .93, respectively). BMI‐SDS was not different across HbA1c groups; 75 mmol/mol (>9.0%) in 2004 (p = .873), 2010 (p = .10) or 2016 (p = .630). Mean HbA1c decreased from 2004 to 2016 in the 10–13 year (69 mmol/mol (8.4%) vs. 57 mmol/mol (7.4%), p =
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