Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population

Autor: Zhang Wei, Wang Tiandong, Li Yang, Meng Huaxing, Min Guowen, Fang Yalan, Niu Xiaoyuan
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Parkinson's Disease, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 2090-8083
2042-0080
DOI: 10.1155/2016/9539836
Popis: Background. Homocysteine (Hcy) levels were higher in patients with Parkinson’s disease (PD). This could be partially explained by levodopa treatment. Whether untreated PD patients have higher Hcy levels is contradictory. Methods. A community-based study was conducted using a two-stage approach for subjects ≥ 55 years to find PD patients in 3 towns of Lüliang City. Blood samples were collected. Serum Hcy, folate, and vitamin B12 concentrations were measured. For each untreated PD patient, 5 controls were selected matched with age and sex to evaluate the relationship between Hcy levels and PD. Results. Of 6338 eligible residents, 72.7% participated in the study. 31 PD cases were identified. The crude prevalence of PD for people ≥ 55 years was 0.67%. Blood samples were collected from 1845 subjects, including 17 untreated PD patients. There was no difference for concentrations of serum Hcy, folate, and vitamin B12 between cases and controls (P>0.05). In univariate and multivariate analysis, there was significant inverse relation between PD and current smoking (P
Databáze: Directory of Open Access Journals
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