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Background Overweight and obesity are major risk factors for many chronic diseases, with the prevalence of overweight/obesity among Chinese adults reaching 50.7% in 2018. Bariatric surgery is one currently available treatment for obesity, but whether it increases the risk of fracture is still controversial. Objective To analyze whether weight-loss surgery will increase the risk of fracture. Methods PubMed, Embase, and Cochrane Library databases were searched for studies (cohort studies, case-control studies, and randomized controlled trial) about the risk of fracture and bariatric surgery published between January 2010 and November 2021. The Newcastle-Ottawa scale (NOS) and Jadad scale were used to evaluate the methodological quality of the studies. RevMan 5.3 and Stata 12.0 were used for data analysis. The Begg's test and Egger's test were conducted to assessing the potential publication bias. Compare the association of bariatric surgery with risk of fracture by comparing risk of fracture between patients with and without bariatric surgery. Results A total of 15 studies were included, including 12 cohort studies, two case-control studies, and one randomized controlled trial, all of which were of high quality. Twelve studies compared the risk of fracture between patients with bariatric surgery and those without, 10 of which enrolled patients with bariatric surgery (surgery group, n=137 239) and obese patients without bariatric surgery (obesity group, n=159 066) with no differences in baseline BMI, showing large heterogeneity (P |
