In laying hens, chronic heat stress-induced renal fibrosis is potentially promoted by indoxyl sulfate

Autor:	Fumika Nanto-Hara, Haruhiko Ohtsu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Laying hens Fibrosis Heat stress Indoxyl sulfate Kidney Uremic toxins Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-75066-0
Popis:	Abstract Indoxyl sulfate (IS), a uremic toxin, is a harmful factor that damages kidneys. Chronic heat stress in laying hens causes renal injury; however, whether IS accumulation is involved in this injury remains unknown. We selected 20 Boris brown laying hens (27 weeks old) and randomly assigned them to two groups (n = 10), one group was exposed to chronic heat stress (32 °C for 4 weeks), whereas the other was maintained at 24 °C. Chronic heat exposure significantly increased plasma and renal IS concentrations (P
Databáze:	Directory of Open Access Journals
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