PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER

Autor:	E. E. Shashova, A. V. Doroshenko, L. N. Bondar, E. M. Slonimskaya, I. V. Kondakova
Jazyk:	ruština
Rok vydání:	2017
Předmět:	molecular subtypes of breast cancer сhymotrypsin-like activity of proteasomes caspase-like activity of proteasomes subunits of proteasomes calpain activity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Сибирский онкологический журнал, Vol 16, Iss 3, Pp 33-39 (2017)
Druh dokumentu:	article
ISSN:	1814-4861 2312-3168
DOI:	10.21294/1814-4861-2017-16-3-33-39
Popis:	The characteristics of calpain and proteasome systems in different molecular subtypes of breast cancer were studied. Tumor samples were obtained from 147 breast cancer patients, who were not previously treated with neoadjuvant therapy. Changes in the chymotrypsin-like proteasome activity and the correlation between proteasome and calpain activities were shown in different molecular subtypes of breast cancer. No changes in the calpain activity and proteasome subunits specific for various molecular subtypes of breast cancer were found. Our results show that the proteasome function undergoes changes depending on the receptor expression by tumor cells and this aspect should be further investigated.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/237c11c4bad64dfcbeb3516eb0ebd342 Zobrazit plný text záznamu View record in DOAJ