Ketamine versus propofol for rapid sequence induction in trauma patients: a retrospective study

Autor: Niklas Breindahl, Josefine Baekgaard, Rasmus Ejlersgaard Christensen, Alice Herrlin Jensen, Andreas Creutzburg, Jacob Steinmetz, Lars S. Rasmussen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 29, Iss 1, Pp 1-8 (2021)
Druh dokumentu: article
ISSN: 1757-7241
DOI: 10.1186/s13049-021-00948-5
Popis: Abstract Background Rapid Sequence Induction (RSI) is used for emergency tracheal intubation to minimise the risk of pulmonary aspiration of stomach contents. Ketamine and propofol are two commonly used induction agents for RSI in trauma patients. Yet, no consensus exists on the optimal induction agent for RSI in the trauma population. The aim of this study was to compare 30-day mortality in trauma patients after emergency intubation prehospitally or within 30 min after arrival in the trauma centre using either ketamine or propofol for RSI. Methods In this investigator-initiated, retrospective study we included adult trauma patients emergently intubated with ketamine or propofol registered in the local trauma registry at Rigshospitalet, a tertiary university hospital that hosts a level-1 trauma centre. The primary outcome was 30-day mortality. Secondary outcomes included hospital and Intensive Care Unit length of stay as well as duration of mechanical ventilation. We analysed outcomes using multivariable logistic regression models adjusting for age, sex, injury severity score, shock (systolic blood pressure
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