Innate immune sensors for detecting nucleic acids during infection

Autor: Ghoreshi Zohreh-alsadat, Nakhaee Mohsen, Samie Mohammad, Zak Mohsen Sharif, Arefinia Nasir
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Laboratory Medicine, Vol 46, Iss 3, Pp 155-164 (2022)
Druh dokumentu: article
ISSN: 2567-9430
2567-9449
DOI: 10.1515/labmed-2021-0173
Popis: Innate immune receptors detect nucleic acids, such as viruses, and initiate an immune response by secreting interferon (IFN) and regulating IFN-stimulated genes (ISG). in autoimmune conditions, expression of ISGs funded, show the activation of nucleic acid sensory pathways. However, the nucleus-localized innate sensors are recently found to detect pathogenic nucleic acids for initiating innate response, demonstrating a complicated crosstalk with cytoplasmic sensors and signaling molecules to form an elaborate tiered innate signaling network between nucleus and cytoplasm. to sustain immune hemostasis, these innate immune sensors develop different strategies for discriminating between self or non-self-nucleic acid. We reviewed all the sensors involved in the innate immune system in the present study. A better understanding of these sensors can lead to new treatments for infections, cancer, and autoimmune and inflammatory disorders.
Databáze: Directory of Open Access Journals